Adenovector GAD65 Gene Delivery into the Rat Trigeminal Ganglion Produces Orofacial Analgesia
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چکیده
منابع مشابه
Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
BACKGROUND Our goal is to use gene therapy to alleviate pain by targeting glial cells. In an animal model of facial pain we tested the effect of transfecting the glutamic acid decarboxylase (GAD) gene into satellite glial cells (SGCs) of the trigeminal ganglion by using a serotype 5 adenovector with high tropisms for glial cells. We postulated that GABA produced from the expression of GAD would...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2009
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-5-42